Allogeneic Stem Cell Transplantation (Contemporary Hematology)
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- Hematology Ward & Stem Cell Transplantation Unit.
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Search for articles by this author. Abstract Abstract. Published online January 31, Export Citation.
Restoring T-Cell Immunity Following Allogeneic Hematopoietic Stem Cell Transplantation
Track Citation. Laura Michaelis introduces the The Hematologist print redesign, including a better layout, more modern look, and clearer signposts within.
Chowdhury and Mead review a study that provides insights into cellular heterogeneity of mouse bone marrow stromal cells, which serve as a comprehensive resource for re. J Clin Oncol ; Allogeneic stem cell transplantation SCT provides a curative option for many patients with relapsed hematologic malignancies and for others with high risk of recurrence after initial therapy. Traditionally HLA-matched sibling donors were preferred as the source of stem cells, but the availability of such a donor in only about one-third of patients has led to the use of matched unrelated donors.
This French multicenter study assessed the outcomes for patients with standard-risk hematologic malignancies undergoing allogeneic SCT from related versus unrelated donors, utilizing a uniform pre-transplant conditioning regimen of total body irradiation plus high-dose cyclophosphamide and uniform graft-versus-host disease GVHD prophylaxis with cyclosporin-A and short-course methotrexate for all patients.
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The study population included patients with acute leukemia in first or second complete remission, CML, and myelodysplastic syndrome. In Finland, you may choose where you want to have your treatment, and in accordance with this principle, patients are welcome from all over Finland to our hematology ward.
For this, a referral from your doctor is needed. The rooms may be used for isolation of patients at risk of infection, if needed.
All patient rooms have large, bright windows and are equipped with a refrigerator, television, wireless web and a nurse-call system. Each room has toilet and shower facilities.
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Family and close of kin are welcome to visit patients at the ward. Visiting hours are from 1 to 7 PM 13 to 19 hours ; visiting times to patients in single rooms are flexible. Persons with any infectious disease, including the common cold and the flu, are not allowed to visit the ward because of the risk of spreading the disease to patients.
We work in close collaboration with the laboratory. Hematological diseases may be treated with medicines or stem cell transplantation.
Allogeneic Stem Cell Transplantation by Hillard M. Lazarus
The stem cells are cells produced by the bone marrow. All blood cells develop from the stem cells. A stem cell transplantation is a procedure by which stem cells collected from the circulating blood or from the bone marrow are given by infusion to the patient.
The primary donor is a sibling, if suitable. If not, a suitable donor will usually be identified through searches in international stem cell donor registers. These registers have a database of some 30 million voluntary donors.